英文名称CSNK2B/CK II beta
中文名称丝/苏氨酸蛋白激酶II β重组兔单抗
别    名Casein kinase 2 beta polypeptide; casein kinase IIβ; Casein kinase II subunit beta; CK II beta; CK2B; CK2N; CSK2B; CSK2B_HUMAN; CSNK 2B; CSNK2B; G5A; MGC138222; MGC138224; Phosvitin; Protein G5a.  
研究领域肿瘤  细胞生物  信号转导  干细胞  细胞周期蛋白  转录调节因子  激酶和磷酸酶  
抗体来源Rabbit
克隆类型Monoclonal
克 隆 号2C9
交叉反应Human, Mouse, Rat, 
产品应用WB=1:500-2000 IP=1:10-50 IHC-P=1:50-100 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量25kDa
细胞定位细胞核 细胞浆 细胞膜 细胞外基质 分泌型蛋白 
性    状Liquid
浓    度1mg/ml
免 疫 原KLH conjugated synthetic peptide derived from human CSNK2B/CK II beta 
亚    型IgG
纯化方法affinity purified by Protein A
缓 冲 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
产品介绍This gene encodes the beta subunit of casein kinase II, a ubiquitous protein kinase which regulates metabolic pathways, signal transduction, transcription, translation, and replication. The enzyme is composed of three subunits, alpha, alpha prime and beta, which form a tetrameric holoenzyme. The alpha and alpha prime subunits are catalytic, while the beta subunit serves regulatory functions. The enzyme localizes to the endoplasmic reticulum and the Golgi apparatus. [provided by RefSeq, Jul 2008].

Function:
Participates in Wnt signaling. Plays a complex role in regulating the basal catalytic activity of the alpha subunit.

Subunit:
Tetramer composed of an alpha subunit, an alpha' subunit and two beta subunits. The beta subunit dimerization is mediated by zinc ions. Interacts with TCTEX1D3 (By similarity). Interacts with CD163. Also component of a CK2-SPT16-SSRP1 complex composed of SSRP1, SUPT16H, CSNK2A1, CSNK2A2 and CSNK2B, the complex associating following UV irradiation. Interacts with MUSK; mediates phosphorylation of MUSK by CK2.

Post-translational modifications:
Phosphorylated by alpha subunit.

Similarity:
Belongs to the casein kinase 2 subunit beta family.

SWISS:
P67871

Gene ID:
1460