研究领域细胞生物  免疫学  干细胞  细胞表面分子  淋巴细胞  
抗体来源Rabbit
克隆类型Monoclonal
克 隆 号31G4
交叉反应Human, 
产品应用WB=1:500-1000 IHC-P=1:50-200 IHC-F=1:50-200 ICC=1:50 IF=1:50-200 （石蜡切片需做抗原修复）
not yet tested in other applications.
optimal dilutions/concentrations should be determined by the end user.
理论分子量52~55kDa
细胞定位细胞膜 
性    状Liquid
浓    度1mg/ml
免 疫 原Recombinant human CD14 protein 
亚    型IgG
纯化方法affinity purified by Protein A
缓 冲 液0.01M TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存条件Shipped at 4℃. Store at -20 °C for one year. Avoid repeated freeze/thaw cycles.
注意事项This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
PubMedPubMed
产品介绍The protein encoded by this gene is a surface antigen that is preferentially expressed on monocytes/macrophages. It cooperates with other proteins to mediate the innate immune response to bacterial lipopolysaccharide. Alternative splicing results in multiple transcript variants encoding the same protein. [provided by RefSeq, Mar 2010]

Function:
Cooperates with MD-2 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Up-regulates cell surface molecules, including adhesion molecules.

Subunit:
Belongs to the lipopolysaccharide (LPS) receptor, a multi-protein complex containing at least CD14, MD-2 and TLR4.

Subcellular Location:
Cell membrane; Lipid-anchor, GPI-anchor.

Similarity:
Contains 11 LRR (leucine-rich) repeats.

SWISS:
P08571

Gene ID:
929